4‑Bromophenol: A Versatile Intermediatehttps://www.ketonepharma.com/product/4-bromophenol/

4‑Bromophenol (a.k.a. p‑bromophenol, CAS: 106‑41‑2) is an aromatic phenolic compound bearing a bromine atom at the para position relative to the hydroxyl group. It typically occurs as off‑white or pale crystals with a phenolic smell. Physical properties include a melting point around 63–66 °C and a boiling point near 236–238 °C. tnjchem.com+3ketonepharma+3ChemicalBook+3

It is only sparingly soluble in water but dissolves readily in organic solvents like ethanol, ether, chloroform, and glacial acetic acid. ChemicalBook+3ChemicalBook+3ChemicalBook+3

A common laboratory route to 4‑bromophenol is via electrophilic bromination of phenol under controlled conditions (often using bromine in a suitable solvent, cooled to low temperatures). ChemicalBook+2ChemicalBook+2 Some methods employ carbon disulfide as a solvent, slow addition of bromine, and purification via distillation or recrystallization. ChemicalBook+1 The yields are often in the 80–85 % range. ChemicalBook+1 Advanced synthetic variants (e.g. using N‑bromosuccinimide) are also seen in literature. lookchem.com+1

Ketone Pharma, a manufacturer in India specializing in fine chemicals and intermediates, lists 4‑Bromophenol among its product portfolio, offering high purity grade (≥ 99 %) material for use in organic synthesis, pharma, and specialty chemical markets. ketonepharma+1

Pharmaceutical & Agrochemical Intermediates: Because of its reactivity (due to the bromine substituent), 4‑bromophenol acts as a building block in the synthesis of more complex molecules (APIs, intermediates, functionalized phenols). ketonepharma+2Chem-Impex+2

Organic Synthesis: It participates in coupling reactions, substitution reactions, and as a scaffold for further functionalization. ChemicalBook+2ChemicalBook+2

Dyes & Pigments: It finds usage in the manufacture of specialty dyes, pigments, and phenolic resins. Chem-Impex+2ChemicalBook+2

Research & Lab Reagent: In academic and industrial labs, 4‑bromophenol is used to explore reaction mechanisms, assay intermediates, and test synthetic methods.

4‑Bromophenol is irritating to skin, eyes, and respiratory tract. It is classified under GHS hazard categories:

H315: Causes skin irritation

H319: Causes serious eye irritation

H335: May cause respiratory irritation ketonepharma+1

Precautions include:

Use in a fume hood

Wear protective gloves, goggles, lab coat

Avoid inhalation or direct contact

Store in a cool, dry, well‑ventilated place away from oxidizers, light, and heat sources

Dispose of waste following local chemical waste protocols ChemicalBook+2ketonepharma+2

According to the SDS from ChemicalBook India, acute oral toxicity (mouse) is LD₅₀ ~ 523 mg/kg. ChemicalBook

When sourcing 4‑bromophenol (for example, from Ketone Pharma), key parameters to check are:

Purity / assay: Typically ≥ 98–99 %

Impurities: Unreacted phenol, dibromo / polybromo side products

Moisture content & water content

Crystallinity & physical form (fine powder, crystals)

Certificate of Analysis (CoA), batch data, safety datasheets

Ketone Pharma’s product page indicates these quality attributes and provides the chemical, physical, and safety profile.