The Ledger hardware wallet is one of the most well-liked solutions for hardware wallets for protecting crypto currencies as of my most recent update in September 2021. A popular Ethereum wallet that enables users to connect with decentralized applications (DApps) and manage their Ethereum-based assets is the MetaMask Chrome plugin.

There have been some documented problems with utilising Ledger with the MetaMask Chrome plugin, mostly because of how these two parts work together. Here are some typical problems and potential solutions:

Causes for the failure of the MetaMask Chrome Extension to connect to Ledger

By taking a look at the major reasons that are responsible for this issue, we'll be able to find out a working remedy to get the issue fixed and connect MetaMask to Ledger without any issues. Here are the probable reasons:

Ledger, on its official website, has confirmed that there are a lot of users who are facing similar issues and this is due to some technical glitch at their end. As a result of this, they have released a statement wherein they have said that their team is working hard to resolve the issueIf you are using a web browser that is not supported by Ledger, then you'll definitely face issues while connecting MetaMask to your Ledger deviceWhen MetaMask Chrome Extension does not work with the ledger, it is typically due to an outdated web browser that you are using with your MetaMask wallet.Apart from that, an outdated Ledger firmware can also result in this issueHere's how you can fix the issue 

Now that we know a few reasons why MetaMask not connecting to Ledger, it is time now to gear up and learn how you can fix this issue instantly. Try out the solutions that I have mentioned hereby:

Update the browser extension

When you attempt to link your MetaMask Chrome extension with a hardware wallet or load a wallet onto it, problems may arise if it is out-of-date. Therefore, it is crucial that you constantly install the MetaMask updates in order to have a pleasant experience with MetaMask.

Update the browser 

If you are operating MetaMask through its web browser extension, you need to make sure that the browser you are using is up-to-date. So, go to the settings of your browser and install its latest updates.

Update the Ledger firmware 

This is another sure-short solution that has worked for users when MetaMask not connecting to Ledger. To do so, you need to go to the "Manager" tab and if the update is available, select the "Update firmware" option to go ahead.

Summing up the read: 

The range of wallets, extensions, and firmware can change over time, therefore for the most up-to-date information on utilising Ledger with MetaMask, always consult the official support channels and documentation.