Introduction [url=https://www.lifechempharma.com/product/1-boc-piperazine/] 1-Boc Piperazine [/url]

 (tert-Butyl 4-piperazinecarboxylate) is a widely used protected amine intermediate in pharmaceutical and chemical research. The BOC (tert-butyloxycarbonyl) group acts as a protecting group on the nitrogen of the piperazine ring, enabling selective reactions and minimizing undesired side reactions during synthesis.

Chemical Identity

IUPAC Name: tert-Butyl 4-piperazinecarboxylate

Molecular Formula: C9H18N2O2

Molecular Weight: 186.25 g/mol

CAS Number: 57260-71-6

Appearance: White to off-white crystalline powder

Solubility: Soluble in common organic solvents like dichloromethane, ethanol, and DMF

Key Features

Protected Secondary Amine: Allows for stepwise synthesis in multi-step pharmaceutical processes

Stable Under Mild Conditions: The BOC group can be easily removed under acidic conditions without affecting other functional groups

Compatible with Peptide and API Synthesis

Applications of 1-BOC Piperazine1. Pharmaceutical Intermediate

Commonly used in the synthesis of various active pharmaceutical ingredients (APIs), particularly in oncology, anti-inflammatory, and CNS drugs.

2. Custom Synthesis

Ideal building block for creating diverse heterocyclic structures in research and development laboratories.

3. Peptide Chemistry

Serves as a protected amine component in solid-phase peptide synthesis (SPPS) or solution-phase methods.

Deprotection Conditions

Reagents Used: Trifluoroacetic acid (TFA), HCl in dioxane

Conditions: Typically performed at room temperature

Product Formed: Free amine (piperazine derivative)

Storage and Handling

Store in a cool, dry place, away from moisture and direct sunlight

Use gloves and goggles when handling

Stable under ambient conditions, but recommended to avoid prolonged exposure to air

Packaging and Availability

Available in:

Laboratory Packs: 1g, 5g, 10g, 25g

Bulk Quantities: 100g, 500g, 1kg, 5kg drums

Each lot is delivered with a Certificate of Analysis (COA) and Material Safety Data Sheet (MSDS).

Conclusion

1-BOC Piperazine is an essential protected intermediate widely applied in the synthesis of pharmaceutical compounds and advanced intermediates. Its BOC protection ensures flexibility in complex organic synthesis, making it a go-to choice for R&D and industrial scale-up.

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